Major Depressive Disorder (MDD) is characterized by persistent sadness, loss of interest, and disruptions in sleep, energy, and concentration that impair daily life. This page summarizes evidence-based practices proven effective for treating depression, including Cognitive Behavioral Therapy (CBT), Behavioral Activation (BA), Interpersonal Psychotherapy (IPT), and Mindfulness-Based Cognitive Therapy (MBCT). It also outlines best-practice assessment tools, treatment components, and key considerations to help clinicians deliver responsive, evidence-informed care.